120例乳腺癌中雌激素受体、孕激素受体及癌基因的表达与临床病理因素相关性分析

The expressions of C-erbB-2,ER,PR in breast cancer and prognostic signif icance

目的:探讨乳腺癌组织中C-erbB-2和ER,PR表达及其与临床病理关系。方法:采用免疫组化SP法,检测120例乳腺癌组织中C-erbB-2,ER,PR表达,分析它们之间的表达关系及其临床病理意义。结果:C-erbB-2阳性率在ER阳性组为47.60%,在ER阴性组为69.40%;C-erbB-2阳性率在PR阳性组为50.70%,在PR阴性组为69.40%;C-erbB-2总阳性率为60.83%,在无淋巴结转移组为48.55%,有淋巴结转移组为70.69%。结论:C-erbB-2与ER,PR表达呈负相关,而与淋巴结转移呈正相关;C-erbB-2过度表达预示乳腺癌预后不良。

Objective：To study the expression of C-erbB-2 , ER and PR in breast cancer. Methods： The expressions of C-erbB-2 , ER and PR were detected by immunohistochemistry method. Results： The expression of C-erbB-2was higher and the expressions of ER and PR were lower in tumor tissues with lymph node involved than that of lymph node uninvolved. The expression of C-erbB-2 had an increased tendency with stage Ⅰ, stage Ⅱ and stage Ⅲ. Conclusion： The expression of C-erbB-2 is megatively related with the expression of ER and PR and related to the bad prognosis in breast cancer.