泡桐甲素药理作用的实验研究

The Experiment Studies on Pharmcological Action of Paulownin

采用二甲苯致小鼠耳廓肿胀法、小鼠醋酸扭体法、小鼠碳末廓清法、葡萄糖引起高血糖小鼠模型,观察泡桐甲素抗炎、镇痛、免疫、降糖的药理作用,并对泡桐甲素进行急性毒性试验。小鼠40只,随机分为正常对照组、阿斯匹林组、泡桐甲素高剂量组和低剂量组。结果显示,泡桐甲素高剂量组能明显抑制二甲苯引起的小鼠耳肿胀;泡桐甲素高、低剂量能减少醋酸所致小鼠扭体次数,能提高单核巨噬细胞的吞噬功能;泡桐甲素高剂量组能显著降低血糖,低剂量有一定的降糖作用。急性毒性试验的最大给药量为4.5g/kg,小鼠增重正常,未见有异常行为或死亡等情况。泡桐甲素具有抗炎、镇痛、增强免疫、降低血糖作用,而且毒性小。

To observe the anti-inflammation, analgesia, immunite, hypoglycemia action of paulownln. Used the methods of ear swelling cused by xylene,acetic acid twistlng,carbon expurgation and the hyperglycemia induced by glucose, to observe the pharmcological action of paulownin; and acute toxicity was observed. Paulownin in high does could inhibit significantly ear swelling induced by xylene,high and low does could decrease body twisting times induced by acetice,and paulownin in high and low does could increase the phagocytic funtion of mononu clear phagocyte;paulownin in high dose could obviously decrease blood glucose ,and low dose had the action on hypoglycemia in hyperglycemia mice induced by glucose. The acute toxicity test of paulownin showed that its maximum tolerance is 4.5g/kg in mice. Paulownin has the action of anti-inflammation,analgesia, immunity,hypoglycemia and has little toxicity.