糖尿病与结直肠癌发病关系探究

A study of the relationship between diabetes mellitus and colorectal cancer

目的:了解糖尿病与结直肠癌患病的关系,明确糖尿病史对结直肠癌发病的影响,为做好结直肠癌的一级预防提供思路。方法:采用病例对照的方法分析同时期住院的结直肠癌(364例)及非肿瘤患者(733例)与糖尿病相关因素的关系及差异。对比分析两组患者的糖尿病史、糖尿病家族史、并发病情况、吸烟、饮酒等生活行为以及血脂水平等方面的差异。结果:结直肠癌组糖尿病患者患结直肠癌的危险度是非糖尿病患者的1.72倍,有糖尿病家族史者患结直肠癌的危险度也明显增加(OR值为1.64);多因素回归分析显示年龄、性别、糖尿病家族史、冠心病、高血压、吸烟、饮酒及血脂未进入方程,对结直肠癌未见显著影响;糖尿病史对结直肠癌患病具有显著影响。结论:糖尿病与结直肠癌患病存在一定的相关性,糖尿病增加了患结直肠癌的风险性,是结直肠癌患病的独立危险因素。

Objective To explore the relationship between diabetes mellitus （DM） and colorectal cancer （CRC） and better understand the role of a history of DM in the oncogenesis of the malignancy. Methods A case-control study comparing the differences in prior history of DM, family history of DM, lifestyle such as smoking and alcohol intake, and serum levels of cholesterol and triglyceride between 364 patients with CRC who had been hospitalized and 733 non-cancer patients who had also been admitted was conducted to analyze the relationship between CRC and DM-related factors. Results The risk of developing CRC was 1.72-fold higher in diabetic patients than in those without DM and was also markedly elevated in the individuals who had a family history of DM, with an odds ratio of 1.64. The genesis of CRC was significantly affected by prior history of DM but not by age, sex, smoking, alcohol intake, family history of DM, coronary artery disease, hypertension, and serum lipid levels. Conclusion DM is correlated with the oncogenesis of CRC and increases the risk of developing CRC.