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人β-防御素2与输卵管梗阻性不孕的关系 被引量：2

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摘要 目的:探讨输卵管梗阻患者血清人β-防御素2(HβD-2)水平与体外受精-胚胎移植(IVF-ET)临床妊娠率的关系,阐明HβD-2在输卵管梗阻性不孕中的抗感染免疫机制,从而为临床IVF-ET治疗提供理论依据。方法:选择因输卵管梗阻性不孕在我院行IVF-ET的20例患者为IVF-ET组,15例健康女性为对照组。采集两组月经第2天、围排卵期空腹晨血,RIA法测定FSH、LH、E2基础水平,夹心ELISA法测定血清HβD-2水平,并B超监测卵泡发育、子宫内膜厚度及妊娠结局。结果:IVF-ET组血清HβD-2水平较对照组明显增高(P<0.05),且IVF-ET未妊娠组血清HβD-2平均水平已超过正常上限,较妊娠者显著增高(P<0.05)。结论:HβD-2在感染微生物等抗原刺激下表达增加,可通过测量血清HβD-2水平预测体内感染情况及其严重程度,当HβD-2异常增高时,应给予预防性用药,以提高输卵管梗阻性不孕临床妊娠率。
作者 吕淑兰 郭小燕 曹缵孙
机构地区 西安交通大学医学院第一附属医院妇产科 长治医学院
出处 《实用医学杂志》 CAS 2007年第22期3538-3539,共2页 The Journal of Practical Medicine
关键词 输卵管阻塞 HβD-2 IVF-ET 免疫防御
分类号 R711.6 [医药卫生—妇产科学]
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参考文献8

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二级参考文献12

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实用医学杂志
2007年 第22期

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