急性期脑卒中患者早期外周血白细胞计数变化对近期预后的影响

The significance of short-term prognosis on the change of leukocyte count in stroke patients

目的旨在阐述白细胞在脑卒中患者急性期所起的作用及其对脑卒中患者近期预后的影响。方法随机抽取脑卒中患者250例,根据白细胞计数高低分成白细胞增高组和白细胞正常组,并按卒中性质、卒中部位、血肿大小、梗塞面积、以及近期预后进行统计分析。结果脑卒中患者在急性期白细胞常增高,表现为白细胞总数与中性粒细胞计数增高(P<0.005),而且血肿体积越大、梗塞面积越大白细胞总数与中性粒细胞计数越高(P<0.050)。结论白细胞在脑卒中的发病和脑损害中起着重要作用,在卒中急性期,白细胞总数及中性粒细胞比例越高,近期神经功能预后越差(P<0.050),在临床上可作为判断病情及预后的参考指标之一。

Objective To investigate the significance of short-term prognosis on the change of leukocyte count in stroke patients. Methods Two hundred-fifty patients with stroke were divided into hemorrhagic group and infarct group,the leukocyte count and differential blood count were measured in 24 hours after onset of stroke, and in terms of leukocyte count in normal range or over the range all cases were redivided into two sub-groups： normal sub-group and high leukocyte count sub-group. The clinical data of all cases were analysed and compared with each other. Results In high leukocyte count sub-group the patients＇ volume of hematoma or area of infarction Was larger than that in normal count sub-group （P〈0.005） regardless of the cases of hemorrhagic or infarct group, and after 3 weeks treatment the mortality was also higher and the effective rate was lower （P〈0.005）. Conclusion The change of leukocyte can reflect the severity of stroke and it may serve as a prognostic indication in clinic.