激光生物刺激作用的生物信息模型(英文)

Biolnformation Model of LowEnergy Laser lrradiation

在细胞水平上，本文从生物光子学的角度研究了激光的生物刺激作用，提出了激光生物刺激作用的生物信息模型（ＢＩＭＬ）。ＢＩＭＬ假设，细胞生色团对弱激光的吸收允许弱激光光子象激素一样成为生物信息的载体。对于细胞膜上的生色团，ＢＩＭＬ进一步假设红、橙、黄等暖色激光通过Ｇｉ蛋白活化ｃＡＭＰ的磷酸二酯酶，通过Ｇｇ蛋白活化磷酯酶Ｃ或活化蛋白激酶关联受体使胞内ｃＡＭＰ水平降低；绿、蓝、紫等冷色激光通过Ｇｓ蛋白活化腺苷酸环化酶使胞内ｃＡＭＰ水平升高。本文通过应用验证了ＢＩＭＬ。

In this paper,we study laser biostimulation from the viewpoint of biophotonics at the cellular level,and put forward the bioinformation model on laser biostimulation(BIML).BIML supposes the chromophore absorption allows the photon of lowenergy laser irradiation to act as a carrier of bioinformation as a hormone does.For membrane chromophore, BIML further supposes the chromophore absorption in the cell membrane couples with intracellular messenger and mediates the bioinformation function of lowenergy laser irradiation as following: Hotcolor (red, orange, yellow) laser irradiation activates cAMP phosphodiesterase through G i protein,phosphoinositide phospholipase C through Gg protein,on proteinkinasecorrelated membrenebound receptors: cAMP↓;Coldcolor (green,blue,violet)laser irradiation activates adenylate cyclase through G s protein:cAMP↑.BIML is verified by its successful applications,and its reasonability is shown from the viewpoint of time quantum mechanics.