泛素-蛋白酶体途径在病毒感染中的作用

Roles of the Ubiquitin-proteasome Pathway in the Viral Infection

泛素-蛋白酶体途径——降解溶酶体外蛋白的主要细胞内系统,在许多细胞功能中发挥重要作用。为自身利益如病毒出芽、凋亡抑制和免疫逃避,许多病毒已经进化出了利用泛素-蛋白酶体途径的不同策略。深入理解泛素-蛋白酶体途径在病毒感染中的作用有助于揭示一些病毒病的致病机理和发现新的分子靶标以开发抗病毒药物。因此,将泛素-蛋白酶体途径在病毒感染中的作用方面的最新进展作一综述。

The ubiquitin-proteasome pathway,a major intracellular system for extralysosomal protein degradation, plays an important role in a wide variety of cellular functions, Many viruses have evolved different strategies to utifize the ubiquitin-proteasome pathway for their own benefits,such as virus budding,apoptosis suppression and immune evasion. A better understanding of the roles of the ubiqttitin-proteasome pathway in the viral infection is very helpful to reveal the pathogenesis of viral diseases and discover novel molecular targets for developing antiviral reagents. Therefore, the latest progress on the roles of the ubiquitin-proteasome pathway in the viral infection are reviewed in the paper,