噻诺啡抑制羟考酮依赖的小鼠和大鼠戒断症状的实验研究

Effects of Thenorphine on Oxycodone-Induced Physical Dependence in Mice and Rats

目的观察噻诺啡对羟考酮依赖的小鼠和大鼠纳络酮催促后戒断症状的影响。方法以5 d连续递增给药的方式建立羟考酮依赖的小鼠和大鼠模型,末次给药后采用纳络酮催促戒断,观测小鼠和大鼠戒断症状的发生。同时,噻诺啡伴随羟考酮给药,考查噻诺啡对羟考酮依赖的小鼠和大鼠纳络酮催促后戒断症状的影响。结果噻诺啡(0.062 5,0.25,1.0 mg.kg-1)能显著抑制羟考酮依赖的小鼠戒断时跳跃反应和体重的降低;噻诺啡(0.25,1.0 mg.kg-1)能显著降低羟考酮依赖大鼠的戒断症状评分和体重的降低。在这两种动物模型上,噻诺啡抗羟考酮依赖作用强度均有剂量相关性。结论噻诺啡可抑制羟考酮引起的小鼠、大鼠躯体依赖。

OBJECTIVE To study effects of thenorphine on oxycodone-induced physical dependence. METHODS Mice and rats were administrated with doses of oxycodone to induce physical dependence. Withdrawal syndromes were precipitated 6 h following the last administration of oxycodone by the injection of naloxone （5 mg·kg^-1, ip）. RESULTS Thenorphine （ 0. 062 5,0. 25,1.0 mg·kg^-1 ） inhibited jumping and loss of body weight in oxyeodone-dependent mice. Thenorphine,at the doses of 0. 25,1.0 mg·kg^-1, inhibited withdrawal syndromes and loss of body weight in oxyeodone-dependent rats. CONCLUSION The present results indicated that thenorphine might inhibit withdrawal syndromes in oxyeodone-dependent mice and rats.