与热休克蛋白70相关的抗病毒药物研究进展

Progress in he evelopment f Antiviral Agents elative to Heat hock rotein 70

热休克蛋白70(Hsp70)是一类结构上高度保守的应激蛋白,对细胞起重要保护作用。Hsp70在许多DNA病毒和RNA病毒(如HIV、流感病毒、鼻病毒、多瘤病毒和乳头状瘤病毒等)的感染中均呈现高表达。Hsp70诱导剂及协诱导剂(如环戊烯酮类前列腺素、甘草酸等)的抗病毒作用机制不同于已有的抗病毒药物,可以通过诱导或增强Hsp70的合成而表现出抗病毒活性。本文对Hsp70与病毒复制或感染之间的关系以及与之相关的具抗病毒活性化合物的研究进展进行综述。

Abstract： Heat shock protein 70 （Hsp70） was classified as a family of highly conserved stress proteins, and could protect cells from harmful assaults in both in vivo and in vitro experimental models. It has presented a high level of expression in a wide range of DNA and RNA virus infected cells, including the cells infected with HIV, influenza virus, rhinovirus, polyomavirus and papillomavirus. HspT0 inducers and coinducers, such as cyclopentenone prostaglandins and glycyrrhizin etc., enhance the antiviral activity through inducing Hsp70 synthesis of virus infected cells, which demonstrates an action mechanism different from those of other antiviral agents in clinic use. This review mainly focuses on the research progress of Hsp70 relative antiviral agents and summarizes the references between Hsp70 and viral replication or infection,.