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基质金属蛋白酶-2单核苷酸多态性与非小细胞肺癌的关系 被引量：1

Association Polymorphisms in the Matrix Metalloproteinases-2(MMP-2) Gene with Non-small Cell Lung Cancer
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摘要 目的:研究基质金属蛋白酶-2(MMP-2)单核苷酸多态性与非小细胞肺癌(NSCLC)的关系。方法:以聚合酶链反应和DNA测序等基因多态性分析方法,分别检测非小细胞肺癌患者和正常对照MMP-2-1306T/C基因型,比较不同基因型与肺癌的关系。结果:与MMP-2-1306TT或MMP-2-1306CT基因型携带者比较,MMP-2-1306CC基因型携带者的非小细胞肺癌易感性较高。结论:MMP-2基因的多态性可能与非小细胞肺癌的遗传易感性有关。 Objective： To investigate the association of polymorphisms in the matrix metalloproteinases-2（MMP-2） gene with non-small-cell lung cancer（NSCLC）.Methods： MMP-2-1306T/C polymorphisms in patients with NSCLC and matched health controls were detected by polymerase chain reaction and DNA sequencing.Results： Subjects with MMP-2-1306CC genotype had an increased risk of developing NSCLC compared with those with the MMP-2-1306TT or CT genotype.Conclusion： MMP-2-1306T/C polymorphisms may be associated with genetic susceptibility to NSCLC.
作者 宋晓玉 李力 张莉 熊英
机构地区 四川省肿瘤医院
出处 《四川肿瘤防治》 2007年第4期257-258,282,共3页 Sichuan Journal of Cancer Control
关键词 非小细胞肺癌 MMP-2 基因多态性 Non-small-cell Lung Cancer（NSCLC）,Matrix Metalloproteinase-2（MMP-2）,Genetic Polymorphisms
分类号 R734.2 [医药卫生—肿瘤]
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参考文献8

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同被引文献17

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四川肿瘤防治
2007年 第4期

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