1Semenza GL,Nejfeh MK,Chi S M,et al.Hypoxia inducible nuclear factors bind to an enhancer element located 3 to the hu Ⅱ lan erythropoietin gene[J].Proc Natl Acad Sci USA,1991,88(13):5680-5684.
2Brahimi-Hom C,Mazure N,Pouyssegur J.Signalling via the hypoxia-inducible factor-lα requires multiple post translational modifications[J].Cell Signal,2005,17(1):1-9.
3Yeo EJ,Chun YS Park JW.New anticancer strategies targeting HIF-1[J].Biochem Pharmacol,2004,68(6):1061-1069.
4Zagórska A,Dulak J.HIF-1:the knowns and unknowns of hypoxia sensing[J].Acta Biochim Pol,2004,51 (3):563-585.
5Bardos JI,Ashcroft M.Negative and positive regulation of HIF-1:a complex network[J].Biochim Biophys Acta,2005,1755(2):107-120.
7Jiang BH,Semenza GL,Bauer C,et al.Hypoxia inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension[J].AmJ Physiol,1996,271(4Pt1):1172-1180.
8Semenza GL.HIF-1:mediator of physiologyical and pathop-hysiological responses to Hypoxia[J].J Appl Physiol,2000,88(4):1474-1480.
9Talks KL,Turley H,Gatter KC,et al.The expression and distribution of the hypoxia-inducible factors HIF-I alpha and HIF HIF-2 alpha in normal human tissues,cancers,and tumoassociated macrophages[J].Am J Pathol,2000,157(2):411-421.
10Bos R,Zhong H,Hanrahan CF,et al.Levels of hypoxia-in-ducible factor 1 alpha during breast carcinogenesis[J].Natl Cancer Inst,2002,93:309-314.
二级参考文献26
1Tian H, Hammer RE, Matsumoto AM, et al. The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev, 1998,12(21 ): 3320-3324.
2Talks KL, Turley H, Gatter KC, et al. The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol,2000, 157(2) :411-421
3Gu YZ, Moran SM, Hogenesch JB, et al. Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha. Gene Expr, 1998, 7(3):205-213.
4Zhong H, De Marzo AM, Laughner E, et al. Overexpression of hypoxiainducible factor lalpha in common human cancers and their metastases.Cancer Res, 1999, 59(22) :5830-5835
5Na X, Wu G, Ryan CK, et al. Overproduction of vascular endothelial growth factor related to von Hippel-Lindau tumor suppressor gene mutations and hypoxia-inducible factor-1 alpha expression in renal cell carcinomas. J Urol, 2003, 170(2 Pt 1):588-592.
6Liu MY, Pcellinger L, Walker CL. Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene. Cancer Res, 2003,63 (10): 2675-2680.
7Mizukami Y, Li J, Zhang X, et al. Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer. Cancer Res, 2004, 64(5): 1765-1772.
8Bos R, van der Groep P, Greijer AE, et al. Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma. Cancer, 2003,97(6): 1573-1581.
9Buchler P, Rebar HA, Buchler M, et al. Hypoxia-inducible factor 1 regulates vascular endothelial growth factor expression in human pancreatic cancer. Pancreas, 2003,26(1) :56-64.
10Sivridis E, Giatromanolaki A, Gatter KC, et al. Association of hypoxiainducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma. Cancer, 2002,95(5): 1055-1063.
5Evans SM Koch CJ. Prognostic significance of tumor oxygenation in humans. Cancer Lett, 2003, 195 ( 1 ): 1-16.
6Toma Dasu I, Dasu A, Karlsson M. The relationship between temporal variation of hypoxia, polarographie measurements and predictions of tumour response to radiation. Phys Med Biol, 2004, 49 (19): 463-475.
8Toma Dasu I, Dasu A, Karlsson M. The relationship between temporal variation of hypoxia, polarographic measurements and predictions of tumour response to radiation. Phys Med Biol, 2004, 49 (19): 463-475.
9Brown JM. Tumor microenvironment and the response, to antieancer thera-py.Concer Biol ther, 2002, 1(5):453.
10Gornicki A, Gutsze A. In vitro effects of ozone on human erythrocyte membranes: an EPR study. Acta BiochimPol, 2000, 47 (4): 963-971.