一起由肺炎克雷伯菌引起院内感染的现场流行病学调查

On-the-spot epidemioiogical investigation of nosocomial infection caused by Klebsiella Pneumonia

目的了解本次院内感染的发病特点和流行特征,为确诊和控制疫情提供参考。方法采用现场流行病学调查方法,掌握现场情况,发病特点,分析流行特征。结果2007年5月26日至6月11日,信阳市某中心医院新生儿重症监护病房(NICU)共收治患者69例,发生院内感染18例,罹患率为26.09%,男女发病差别无统计学意义,症状以腹泻为主,排黄色或黄绿色粘液便。从6份样品中5份检测出肺炎克雷伯菌。传染源为环境贮源,传播途径为接触传播,潜伏期3～5 d,三代头孢霉素治疗有效。结论本次疫情是由肺炎克雷伯菌引起围产期儿童感染性腹泻的院内感染爆发。

Objective The study was conducted to investigate the morbidity and epidemiological characteristics of the nosocomial infection,providing reference for diagnosis and control of the epidemic.Methods On-the-spot epidemiological investigation was used to investigate the field and the morbidity of the disease and analyze the epidemiological characteristics.Results From May 26, 2007 to June 11,69 patients were admitted to the neonatal intensive care unit（NICU）in the Central Hospital in Xinyang City.There were 18 cases of nosocomial infection,the incidence being 26.09%, which was of no significant difference between men and women.Diarrhea was the major symptom, with yellow or yellow-green mucous stool observed.Klebsiella pneumoniae was detected from five samples out of six.The source of infection was the receptacles.The route of transmission was contact. The latent period was 3 to 5 days,and the third generation of cephalosporins was effective against the disease.Conclusion The epidemic was an outbreak of infectious diarrhea among perinatal children caused by Klebsiella pneurnoniae,which was of nosocomial infection.