氯诺昔康复合丙泊酚、芬太尼用于人工流产的止痛疗效研究

Effects of Lornoxicam Combined with Propofol and Fentanyl on Induced Abortion

目的:观察氯诺昔康复合丙泊酚、芬太尼用于无痛人工流产的临床效果。方法:随机将600例早期妊娠妇女分成氯诺昔康组(L组)300例和对照组(P组)300例。麻醉前2h,L组口服氯诺昔康8mg,P组服用安慰剂。观察记录两组麻醉诱导时间、苏醒时间、麻醉用药总量、术后腹痛发生情况和不良反应。结果:术后腹痛L组少于P组(P<0.01),术中丙泊酚用药量L组少于P组(P<0.05)。结论:氯诺昔康用于无痛人工流产可增强麻醉效果,减少丙泊酚用量,减少术后腹痛的发生率。

Objective： To assess the analgesic effect of lornoxicam combined with propofol and fentanyl for the induced abortion period. Method： A randomized, placebo - controlled clinical study were enrolled six hundred women who were terminated the early pregnancy, and divided into lornoxicam group （300 cases） and placebo group（300 cases） randomly. The L group took lornoxicam 8 mg and P group took placebo at 2 hours before surgery. The induction and recovery time of post anesthesia, the quantity of anesthesiadrugs postoperative abdominal pain and incidence of adverse events were observed. Result： Lornoxicam - treated patients administered less quantity of propofol and experienced less abdominal pain compared with the placebo patients（P 〈 0.01 ）. Conclusion： Combination of lornoxicam to propofol and fentanyl provides more powerful anesthetic effects in the termination of early pregnancy, and decrease the incidence of post-operative abdominal pain.