急性胆管损伤后应用磁性胆肠吻合支架一期修复胆肠连续性的实验研究

Application of sutureless magnetic bilioenteric anastomosis stent for one-stage reconstruction of bilioenteric continuity after acute bile duct injury

目的评价自行研制的无缝线磁性胆肠吻合支架在犬急性胆管损伤后、胆管炎症较重的情况下,一期修复胆肠连续性的可行性。方法制造犬的急性胆管损伤并胆汁性腹膜炎模型,在胆管炎症较重的情况下应用磁性胆肠吻合支架进行胆肠连续性的一期修复,观察吻合效果,并与传统手工吻合方式进行比较。结果研制的吻合支架一期修复犬胆肠连续性安全可靠,无吻合口漏和感染发生;胆道造影显示吻合口通畅,无明显狭窄。组织学检查显示吻合口愈合良好,炎症反应小,胶原排列整齐。结论该吻合支架在胆管炎症较重的情况下,进行胆肠连续性的一期修复是安全而且可行的。

Objective To investigate the effect of a new-type sutureless magnetic bilioenteric anastomosis stem for one-stage reconstruction of bilioenteric continuity after aeute bile duct injury. Methods The models of acute bile duct injury and bile peritonitis were established in dogs. The sutureless magnetic bilioenteric anstomosis stent was used to reconstruct the bilioenteric ontinuity onestage in the case of bile duct with severe inflammation. The effect of the stent was then determined and compared with that of the traditional manual anastomosis. Results The stent was safe for use and there were no anastomotic leakage and infection. Biliary tract imaging showed that the anastomosis was unobstructed and there was no obvious stenosis. Histological examination revealed that the anastomosis healed well, inflammation reaction was slight and collagen lined up in order. Conclusions It is safe and feasible to use the stent to reconstruct the bilioenteric continuity one-stage under the condition of severe bile duct inflammation.