卡铂联合金葡素治疗恶性胸腔积液疗效观察

Clinical effect of intrapleural cavity perfusion of carboplatin combined with staphylococcal enterotoxin C treating malignant pleural effusion

目的:观察卡铂(carboplatin,CBP)联合金葡素C(staphylococcal enterotoxin C,SEC)治疗恶性胸腔积液的疗效。方法:104例恶性胸腔积液患者随机分为联合组(36例)、卡铂组(38例)、金葡素组(30例)。联合组36例患者抽尽胸腔积液后,经胸腔内注入卡铂加金葡素进行治疗;卡铂组和金葡素组患者胸腔内只注入卡铂或金葡素。观察3组患者的近期疗效、生活质量改善、毒副反应及生存状况。结果:联合组治疗有效率为83.3%,卡铂组为47.4%,金葡素组为43.3%,3组比较,差异有显著性(P<0.05);治疗后3组患者生活质量均有不同程度的改善,其中联合组卡劳夫斯基评分高于其他两组;联合使用并没有增加毒副反应;3组的中位生存期比较,差异无统计学意义(P>0.05)。结论:卡铂联合金葡素治疗恶性胸腔积液有确切疗效。

Objective：To observe the effect of carboplatin （CBP） combined with staphylococcal Enterotoxin C （SEC） to maglignant pleural effusion. Methods： 104 patients were assigned into three groups randomly. The combine group （36 patients） was treated with CPB and SEC; the CBP group （38 patients） was treated with CBP alone;the SEC group was treated with SEC. The therapeutic effects ,live qulity, side effect,and survival time were surveyed. Results： The effective rates of the combine group ,CBP group and SEC group were 83.3% ,47.4%,43.3% respectively （P〈0.05）. Conclusion： The in- trapleural cavity perfusion of CBP combined with SEC in treating malignant pleural effusion is significantly more effective than that with CBP alone.