热休克蛋白70疫苗在消化道肿瘤研究中的进展

Advancement of Heat Shock Protein 70 Vaccine in Alimentary Canal Cancer

目的综述热休克蛋白70(heat shock protein70,HSP70)疫苗在消化道肿瘤中的研究进展。方法对近年来的相关文献进行分析。结果HSP70能与肿瘤特异性抗原结合,形成HSP70-多肽复合物;它作为"分子伴侣"参与肿瘤免疫作用,激活机体特异和非特异免疫反应。结论HSP70的应用在消化道肿瘤的预防和治疗中显示出诱人的前景。

Objective To review the advancement of heat shock protein 70 （HSP70） vaccine in alimentary canal cancer. Methods Related articles were reviewed. Results HSP70 can integrate with tumor special antigen to form HSP70 polypeptide compound. To activate the special and nonspecial immune response of body, HSP70 can participate in the process of tumor immunity as a ＂molecular partner＂. Conclusion HSP70 has shown alluring perspective in the precaution and treatment of alimentary canal cancer.