504例泌尿生殖系统支原体培养及药敏结果分析

Culturing of urogenital tract mycoplasma and its susceptibility to antibiotics of 504 cases

目的探讨解脲脲原体(Uu)和人型支原体(Mh)在泌尿生殖系统感染中的致病作用及其药敏情况。方法504例泌尿生殖系统感染患者进行支原体培养和9种抗生素的药敏试验。结果504例患者中支原体阳性264例,感染率为52.4%,其中Uu、Mh以及Uu+Mh混合感染的阳性率分别为40.5%、2.2%和9.7%,女性Uu感染率明显高于男性(χ2=21.9,P<0.05),支原体对9种抗生素的敏感性最高的是交沙霉素(99.6%),其次是米诺环素(98.1%)、多西环素(98.1%)和氧氟沙星(88.3%)。Uu+Mh混合感染的耐药率明显高于单一Uu感染(χ2=25.3,P<0.05)。结论泌尿生殖道系统感染主要由解脲脲原体引起,占77.3%,交沙霉素为首选治疗药物。

Objective To explore the pathogenesis of ureaplasma urealyticum（Uu） and mycoplasma hominis（Mh） in urogenital tract infection and their susceptibility to antibiotics.Methods Mycoplasma culture was carried out with the samples of 504 cases and then the susceptibility to 9 kinds of antibitics were detected on positive samples.Results From 504 cases,264 were infected with mycoplasma,the total positive rate was 52.4%,the positive rates of Uu,Mh and their mixed infection were 40.5%,2.2% and 9.7%,respectively.The positive rate of female was higher than that of male（P〈0.05）.The most sensitive antibiotics were JOX（99.6%）,MNO（98.1%）,DOX（98.1%） and OFX（88.1%）.The resistance rate of Uu and Mh mixed infection was higher than Un single infection（χ^2=25.3,P〈0.05）.Conclusion Mycoplasma infection rate is 52.4% in urogenital tract infection.The major mycoplasma is Uu 77.3%.JOX maybe the first choice of drug to treat mycoplasma infection.