曲美他嗪治疗老年慢性充血性心力衰竭的疗效观察

Effecfs of trimetazidine on congestive heart failure in elders

目的:观察曲美他嗪对老年慢性充血性心力衰竭(CHF)的治疗效果。方法:选择CHF患者66例,随机分为2组,对照组30例,采用常规治疗方法,曲美他嗪组36例,在常规治疗的基础上加用曲美他嗪,6个月后比较NYHA心功能分级及左室射血分数,左室短轴缩短率的改善情况。结果:①两组治疗均有效,心功能明显改善。②治疗组的总有效率明显优于对照组(89%vs70%,P<0.05);心功能改善更为显著(P<0.05)。结论:曲美他嗪可改善老年CHF患者的心功能状态,增加运动耐量。

Objective： To evaluate the clinical effect of trimetazidine on congestive heart failure （CHF） in elders.Methods： 66 CHF patients were divied into two groups randomly. In the control group （n=30）,patients were treated with commonly used drugs; In the trimetazidine group （n=36）, patients were treated with commonly used drugs and trimetazidine. NYHA cardiac function grade. LVEF and FS were compared six months later. Results： Both treatments were effective for CHF in elders,and cardiac function was improved ;Effective rate of the trimetazidine group,whose cardiac function was improved significantly（P〈0.05）,was higher than that of the control group （89% vs 70%,P〈0.05）. Conclusion：Trimetazidine is effective in the treatment on CHF in elders.