利培酮治疗冰毒所致精神障碍40例疗效观察

Clinincal effects of risperidone in the treatment of 40 cases with the psychiatric disorder by methamphetamine

目的:观察利培酮治疗甲基苯丙胺(冰毒)所致精神障碍的疗效和不良反应。方法:对80例符合中国精神疾病分类方案与诊断标准第三版(CCMD-3)诊断为冰毒所致精神障碍的患者,随机分为两组:利培酮组40例和安慰剂组40例。采用简明精神病量表、临床疗效总评量表和副反应量表评定患者的精神病性症状、疗效和不良反应。结果:利培酮组有效率为89.9%,安慰剂组为33.6%。两组间差异非常显著(P<0.01)。两组副反应发生率差异无显著性(P>0.05)。结论:利培酮能有效改善冰毒所致的精神病性症状,疗效显著,无明显不良反应发生,安全性好。

Objective： To explore the efficacy and side effects ofrisperidone in the treatment of the cases with the psychiatric disorder by methamphetamine （ICE） .Methods：80 cases who met the CCMD-3 criteria of major psychiatric disorder by ICE were randomly divided into risperidone group 40 cases and control group 40 cases. The efficacy was assessed by Brief Psychiatric Rating Scale（BPRS） and Clinical Global Impression（CGI）,and the side effects were assessed by Treatment Emergent Symptoms Scale （TESS）. Results： The efficacy rates of the risperidone group were 89.9%,and the control group were 33.6%.There were significant difference among the two groups （P 〈 0.01）.The results have no remarkable differences in the two groups （P 〉 0.05）. Conclusion： The results suggested that risperidone was more efficacy, safety and compliance for treatment of the cases with the psychiatric disorder by ICE.