心喘胶囊对犬实验性心力衰竭时神经内分泌过度激活的调节作用研究

Study on the Regulatory Effect of Xinchuan Capsules on the Excessive Aactivation of Neuroendocrine of Dogs with Experimental Heart Failure

目的研究心喘胶囊对心力衰竭时神经内分泌过度激活的调节作用。方法采用静脉泵入戊巴比妥钠复制犬心力衰竭动物模型,十二指肠给予心喘胶囊水提取液,观察各组神经内分泌过度激活相关指标的变化。结果心喘胶囊具有明显提高衰竭心脏心肌细胞β受体密度,降低血浆去甲肾上腺素、肾上腺素水平的作用;还具有明显降低血浆血管紧张素转换酶活性的作用,这方面作用与阳性对照药倍他乐克加开博通作用相似。结论心喘胶囊对心力衰竭时神经内分泌过度激活具有调节作用。提出中医对心力衰竭的治疗,除了针对"心主血脉"功能失调进行治疗外,还应针对"心藏神"功能失调,即心神不宁进行调治。

Objective To investigate the regulatory effect of Xinchuan capsules on the excessive activation of neuroendocrine with heart failure. Methods The heart failure animal model was built up using dogs by intravenous pumping of sodium pentobarbital. Water extract of Xinchuan capsules was given through duodenum. Indicators relating to the excessive activation of neuroendocrine changes of each group were observed. Results Xinchuan capsules could significantly increase the density of beta receptors of failure myocardial cells and lower the level of plasma norepinephrine and epinephrine, and remarkbly decrease the activity of plasma angiotensin converting enzyme. This played the similar role as the positive control drug metoprolol plus captopril. Conclusion Xinchuan capsules have the regulatory effect on the excessive activation of neuroendocrine with heart failure. TCM treatment for heart failure should not only target the functional disorder of the heart dominating blood circulation and vessels, but also the functional disorder of the heart stores the spirit, that is uneasy mental state.