摘要
目的优选青兰浸膏片处方及制粒压片工艺条件。方法采用L9(34)正交试验设计,以颗粒粒度、片芯硬度、脆碎度、崩解度为考察指标,对青兰浸膏片处方及制粒压片工艺条件进行优选。结果最佳工艺为青兰浸膏粉与淀粉、糊精的比例(kg)为25∶4∶1,用青兰浸膏混和粉0.25倍(kg)95%乙醇湿润搅拌8min制软材。结论用优选出的工艺参数制得的片剂综合评分最好,工艺科学合理。
Objective To study the formulation and preparation of Qinglan Jingao tabales. Methods The orthogonal design was taken for the optimization, the contents were selected by granule, rigidity, crack and disintegration. Results The optimum dropping condition was as follow： the rate of Qinglan extraction to starch and dextrin was 25 ： 4 ： 1 （kg）, the added amount of 95% alcohol was 0.25 times （kg）, mix 8 minutes by the wet granule compression technique. Conclusion The optimum extracting procedure is scientific, reasonable and stable.
出处
《中国中医药信息杂志》
CAS
CSCD
2007年第12期52-53,共2页
Chinese Journal of Information on Traditional Chinese Medicine
关键词
青兰浸膏片
芦丁
正交设计
Qinglan Jingao Tabales
formulation and preparation
orthogonal design
