早期充分复苏治疗对感染性休克患者预后影响的探讨

Evaluation of prognosis of early and sufficient resuscitation therapy in patients with septic shock

目的探讨早期充分复苏治疗对感染性休克患者预后的影响。方法将117例感染性休克患者随机分为两组,观察组60例于休克早期(6 h内)即开始进行充分的复苏治疗(早期目标导向治疗),对照组57例按传统方法进行循环与容量支持等常规治疗,比较两组患者的再次复苏率、病死率、脏器功能损害发生率。结果观察组的重要脏器功能好转程度明显优于对照组(P<0.05或<0.01)。观察组的再次复苏率、MODS的发生率、病死率明显低于对照组(P均<0.01)。结论早期充分复苏治疗可明显改善感染性休克患者的预后。

Objective To evaluate the effect of early and sufficient resuscitation on prognosis in patients with septic shock. Methods 117 patients enrolled in this group randomly allocated to two groups, the observation group was in early stage（6 hours）and sufficiently resuscitated （60 patients）, the control group was given conventional therapy with cycle and capacity support（57 patients）, incidence of resuscitate again, mortality and incidence of organ damage were analyzed. Results The vital organ function of the observation group improved significantly better than that of the control group（ P 〈0.05 or 〈0.01）. The incidence of resuscitate again, multiple organ dysfunction syndrome and the mortality of the observation group was significantly lower than that of the control group（ P 〈0.01）. Conclusion The treatment of early and sufficient resuscitation can significantly improve the prognosis of patients with septic shock.