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血清乳酸脱氢酶及β_2-微球蛋白在慢性淋巴细胞白血病中的预后意义

Prognostic Significance of Lactate Dehydrogenase and β_2-microglobulinin in Chronic Lymphocytic Leukemia
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摘要 为了研究血清乳酸脱氢酶(LDH)和β2-微球蛋白(β2-MG)在慢性淋巴细胞白血病(CLL)中的预后价值,回顾性分析了141例CLL患者的LDH、β2-MG水平以及其他临床及实验室检查资料,采用Kaplan-Meier法及Cox回归模型进行生存分析。进行多因素分析时,将LDH和β2-MG表达水平分为3个组,即:①LDH和β2-MG水平均升高;②LDH和β2-MG水平中一个升高;③LDH和β2-MG两者水平均正常。结果表明:BinetC期患者的LDH和β2-MG水平较BinetA期患者明显升高(p=0.034和p=0.036)。β2-MG水平与淋巴细胞计数无明显相关(p=0.756)。经Cox回归分析,BinetC期(p=0.015)和LDH水平升高(p=0.035)与总体生存时间短显著相关,β2-MG水平与总体生存时间无显著相关性(p=0.384)。LDH和β2-MG水平均升高组较均正常组生存期短(p=0.04)。结论:Binet分期及血清LDH水平是影响CLL预后的重要因素。 To evaluate the prognostic value of lactate dehydrogenase (LDH) and β2-microglobulinin (β2-MG ) in chronic lymphocytic leukemia(CLL), a total of 141 cases of CLL had been investigated retrospectively. The Kaplan Meier method was used to estimate the overall and failure-free survival distributions. Cox regression was used in univariate and multivariate analysis of potential predictors for overall survival. In multivariate analysis, the expression levels of LDH and β2-MG were divided into 3 groups : ( 1 ) elevation of both LDH and β2-MG levels; (2) elevation of LDH or β2-MG levels alone; ( 3 ) normal levels' of both LDH and β2-MG. The results showed that serum LDH and β2-MG levels of patients in Binet C were significantly higher than those in Binet A (p = 0. 034 and p = 0. 035 ). The level of serum β2-MG was not correlated with lymhocyte count ( p = 0. 756 ). Binet C and high LDH level were associated with significantly shorter overall survival. β2-MG was not proved to have any association with overall survival. The overall survival time in group of elevation of both LDH and β2-MG levels was shorter than that in group of normal levels of both LDH and β2-MG. It is concluded that serum LDH level and Binet stage are important prognostic factors for CLL.
出处 《中国实验血液学杂志》 CAS CSCD 2007年第6期1305-1308,共4页 Journal of Experimental Hematology
基金 江苏省医学领军人才项目资助 江苏自然科学基金资助项目 编号BK2007249
关键词 慢性淋巴细胞白血病 乳酸脱氢酶 Β2-微球蛋白 Binet分期 淋巴细胞白血病 chronic lymphocytic leukemia lactate dehydrogenase β2-microglobulin binet stage lymphocyticleukemia
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参考文献11

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