白血病细胞对Fas/FasL途径介导凋亡的抵抗及其应对策略

Resistance of Leukemia Cells to Fas/FasL-mediated Apoptosis and Strategies Replying to Antiapoptosis of Leukemia Cells——Review

从细胞凋亡的角度看,造血细胞凋亡过少是造血细胞堆积的原因,Fas/FasL系统作为诱导细胞凋亡的一条重要途径,参与了白血病的发生发展。白血病细胞普遍存在对Fas/FasL途径介导的凋亡不敏感或抵抗,而这也是造成白血病细胞免疫逃逸和对化疗不敏感的重要原因之一。近年来,国内外对白血病Fas/FasL途径介导的凋亡抵抗的机制,诸如Fas/FasL突变及表达异常Fas信号传导途径异常,凋亡调控基因对Fas/FasL系统的调控(NF-κB、XiAP膜受体CD28和基质金属蛋白酶7等)和应对策略的相关研究取得了一些进展。

At angle of cell apoptosis, the excessive less of hematopietic cell apoptosis is a reason of hematopoielac cell accumulation. The Fas/FasL system as an important pathway inducing cell apoptosis participates in occurence and development of leukemia, leukemia cells generally are not sensitive or are resistant to Fas/FasL-mediated apoptosis, while it is one of important reasons resulting in immunoescape and unsensitivity of leukemia cells to chemotherapy. In recent years studies related to mechanisms of leukemia cell resistance to Fas/FasL-mediated apoptosis such as Fas and FasL mutation and expression abnormatity, Fas signaling transduction pathway abnormality, and regulatory affect of apoptotic regulatory genes on Fas/FasL system, as well as strategies replying to antiapoptosis of leukemia cells including NF-Kb, X1AP, membrane receptor CD28 and matrix metalloprotinase 7 obtained some progresses. The above-mentioned issues were reviewed in this article.