三氧化二砷应用于淋巴瘤的基础及临床研究进展

Progression of Foundational and Clinical Studies on Use of Arsenic Trioxide in Treatment of Lymphoma——Review

三氧化二砷治疗急性早幼粒细胞白血病取得成功后又被实验性用于淋巴瘤的治疗,近年来国内外学者在此方面做了大量研究工作,发现三氧化二砷通过多种途径发挥抗淋巴瘤效应,且很多物质能够增强或减弱这种效应,三氧化二砷治疗对其他化疗药物不敏感的复发及难治性淋巴瘤仍有一定效果且毒副作用小,提示三氧化二砷是一种极具潜力的治疗淋巴瘤的新型药物,现就相关基础及临床研究成果进行综述。

Arsenic trioxide has been used to treat lymphoma experimentally since it was used to treat acute promyelocytic leukemia successfully, Massive works in this field have been done throughout the world, It was found that arsenic trioxide exerted an anti-lymphomatic effect via many pathways, and many substances could increase or reduce this effect. Arsenic trioxide can be used to treat relapsed and refractory lymphomas resistant to other chemotherapies with some therapeutic effects and limited side effects, which indicates that arsenic trioxide is a new potential drug for lymphoma, This article is an overview about these foundational and clinical studies.