p53在喉癌中的免疫组化研究及临床意义

Immunohistochemical Study on the p53 in Laryngeal Cancer and its Clinical Significance

本文用ABC免疫组化方法，以抗p53单抗对70例喉良恶性标本研究，探讨p53与喉癌生物学行为及预后的关系。结果表明：p53蛋白在喉癌中的阳性表达率为64．7％，p53蛋白在良性病变中无表达。p53蛋白表达与喉癌病理分级、淋巴结转移、吸烟及预后相关；而与临床分期、年龄及生长部位无关。

Seventy laryngeal cancers and benign diseases had ben studied by ABC immunohistochemical meth ods,using antibody to P53 to find the correlation between p53 and the biological behaviors and prognosisof larygenl carcinoma. The results were as follows:p53 protein was identified in 64.7% of laryngeal carci nomas by means of Pab1801. No immunostaining was found in normal tissues, dysplasia and benign tumortissues. The expression of p53 was more likely to correlate with low degree of cell differentiation, metasta sis to nodes, smoking and poor pognosis. No correlation was found between the expression of p53 and clin ical stage, age and site of tumour.