石蜡包埋癌组织制备的瘤苗(PETV)对荷瘤615小鼠的治疗作用

Immunotherapy of Cancer by Tumor Vaccine Prepared from Paraffin Embeded Cancer Tissue (PEIV) in 615 Mice

应用石蜡包埋的Ca761－YP8／L小鼠移植性乳腺癌组织制备的瘤苗，对荷瘤（Ca761－FP8／L）的615近交系小鼠的治疗作用进行了研究，结果显示：经PETV治疗后小鼠的存活期明显延长，肿瘤的重量明显小于对照组，肺转移率也较对照组降低，应用PETV配合选择性去除Ts细胞的小剂量CTX和增强免疫应答反应的细胞因子INFa－2b可进一步提高疗效。作者认为，PICFV应用范围广，可长期保存抗原等优点，值得深入研究。

Six hundred and fifteen tumor-bearing inbred stain mice were treated with tumor vaccine preparedfrom paraffin embeded cancer tissue (PEIV). The results showed that after treatment, the pulmonarymetastaic rate was reduced, the weight of tumor on 15th day was low and the survival time of 615 tumorbearing inbred strain mice was prolonged. The low dose CTX and INFa-2b can probably enhance the ther apeutical effects. The author considered that PEW has the advantages of pretecting tumor antigen for alongtime and being widely used. It is worth being studied more deeply.