Novozyme 435选择性酸解(R,S)-3-n-丁基苯酞

Enantiomeric Selective Acidolysis of(R,S)-3-n-butylphthalide Catalyzed by Novozyme 435

Novozyme 435可以提高对映体选择性酸解(R,S)-3-n-丁基苯酞。最适的有机溶剂、水分活度、转速和转化时间分别是正己烷、0.54、150 r/min和64 h。在此优化条件下,丁基苯酞的转化率为14.8%,产物的对映体过量值为99.3%。

Novozyme 435 can improve enantiomeric selective acidolysis of （R, S）-3-n-butylphthalide. The optimum organic solvent, water activity, agitation velocity and reaction time are hexane,0. 54,150 r/min and 64 h respectively. 14.8 % conversion rate of （R, S）-3-n-butylphthalide and 99.3% enantiomeric excess of product can be obtained under the optimum reaction condition.