期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

X连锁的凋亡抑制蛋白研究进展 被引量：3

下载PDF
导出
摘要 IAP(inhibitor of apoptosis)是内源性凋亡抑制蛋白家族,其中效力最强的是X连锁凋亡抑制蛋白(X chromosome linked inhibitor of apoptosis protein,XIAP)。它主要通过BIR结构域和RING锌指结构域抑制caspase活性、调节核因子NF2κB并参与信号的转导过程。XIAP受到不均一核糖核酸蛋白C1和C2等的正向调节和XAF1和Smac/DIABLO等的负向调节。近年来XIAP在临床方面的研究也取得了很大进展。
作者 韩岱 霍霞 李燕
机构地区 汕头大学医学院中心实验室
出处 《癌变．畸变．突变》 CAS CSCD 2007年第6期508-510,514,共4页 Carcinogenesis,Teratogenesis & Mutagenesis
基金 广东省自然科学基金资助项目(5008352)
关键词 X连锁凋亡抑制蛋白 凋亡 BIR结构域 XAF1
分类号 Q71 [生物学—分子生物学]
  • 相关文献

参考文献17

  • 1Holcik M, Gordon BW, Komeluk RG. The Internal Ribosome Entry Site-Mediated Translation of Antiapoptotic Protein XIAP Is Modulated by the Heterogeneous Nuclear Ribonucleopro-teins C1 and C2 [J]. Mol Cell Biol,2003,23(1):280-288.
  • 2Yamagiwa Y , Marienfeld C , Meng F , et al. Translational regulation of x-linked inhibitor of apoptosis protein by interleukin-6: a novelmechanism of tumor cell survival[J] Cancer Res,2004,64(4):1 293-1 298.
  • 3Zou T, Rao JN , Guo X , et al . NF-kappaB-mediated IAP expression induces resistance of intestinal epithelial cells to apoptosis after polyamine depletion [J] . Am J Physiol Cell Physiol, 2004, 286(5) : 1009 - 1018.
  • 4Siu PM, Bryner RW, Murlasits Z, et al. Response of XIAP, ARC, and FLIP apoptotic suppressors to 8 wk of treadmill running in rat heart and skeletal muscle[J] . J Appl Physiol 2005, 99(1) : 204- 209.
  • 5Siu PM, Pistilli EE, Ryan MJ, et al. Aging sustains the hypertrophy-associated elevation of apoptotic suppressor X-linked inhibitor of apoptosis protein (MAP) in skeletal muscle during unloading[J] . J Gerontol A Biol Sci Med Sci, 2005, 60(8): 976- 983.
  • 6Piyali D, Rebecca K. Nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating XIAP and surviving [J]. Proc Natl Acad Sci USA, 2006, 103(16) :6332- 6337.
  • 7Scarabelli TM, Stephanou A, Pasini E, et al. Minocycline inhibits caspase activation and reactivation, increases the ratio of XIAP to smac/ DIABLO, and reduces the mitochondrial leakage of cytochrome C and smac/ DIABLO[J] J Am Coll Cardiol, 2004, 43(5) : 865 - 874.
  • 8Berezovskaya O, Schimmer AD, Glinskii AB, et al .Increased expression of apoptosis inhibitor protein XIAP contributes to anoikis resistance of circulating human prostate cancer metastasis precursor cells [J] . Cancer Research, 2005, 65(6) : 2378 - 2386.
  • 9Cummins JM, Kohli M, Rago C, et al, X-linked inhibitor of apoptosis protein (XIAP) is a nonredundant modulator of tumor necrosis factor-Related apoptosis-inducing ligand (TRAIL) -mediated apoptosis in human cancer cells[J] Cancer Research, 2004,64(1): 3006-3008.
  • 10Lacasse EC, Kandimalla ER, Winocour P, at al. Application of XIAP antisense to cancer and other proliferative disorders: Development of AEG35156/ GEM(r) 640[J] Ann NY Acad Sci, 2005,1058:215 - 234.

同被引文献46

  • 1方优红,罗优优,余金丹,楼金玕,陈洁.55例极早发炎症性肠病患儿的临床特点分析[J].中华炎性肠病杂志（中英文）,2019,3(3):233-237. 被引量：7
  • 2苏雯,许春娣,王歆琼,余熠,郭燕,许旭,肖园.三十例极早发型炎症性肠病患儿的临床表型和基因特点分析[J].中华炎性肠病杂志（中英文）,2018,2(2):83-88. 被引量：8
  • 3申晓婷(综述),陈洁(审校).Rho/ROCK信号通路与炎症性肠病[J].国际儿科学杂志,2018,45(9):697-700. 被引量：3
  • 4刘静,李树青.心肌缺血再灌注损伤诱发细胞凋亡的研究进展[J].中国心血管病研究,2005,3(12):951-953. 被引量：8
  • 5Cohen GM.Caspases:the excutionners of apoptosis.Biol Chem J,1997,326:1-16.
  • 6Takahashi R,Deveraux Q,Tamm l,et al.A single BIR domain of XIAP sufficient for inhibiting caspases.J Biol Chem,1998,273:7787-7790.
  • 7Liu HR,Gao EH,Hu AH,et al.Role of Omi/HtrA2 in apoptotic cell death after myocardial ischemia and reperfusion.Circulation,2005,11:90-96.
  • 8Gottlieb RA,Burleson KO,Kloner RA,et al.Reperfusion injury induces apoptosis in rabbit cardiomyocytes.J Clin Invest,1994,94:1621-1628.
  • 9Black SC,Huang JQ,Rezaiofar P,et al.Co-localization of the cysteine protease caspase-3 with apoptotie myocytes after in vivo myocardial iachemia and reperfusion in the rat.Mol Cell Cardiol,1998,30:733-742.
  • 10Okamura T,Miura T,Takemura G.Effect of caspase inhibitors on myocardial infarct size and myocyte DNA fragmentation in the ischemia-reperfused rat heart.Cardiovasc Res,2000,5:642-650.

引证文献3

二级引证文献4

癌变．畸变．突变
2007年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部