鱼肝油酸钠乙醇混合液肝癌瘤内注射的临床初步应用

Sodium Morrhuate Pure Alcohol Mixture Injection for Liver Carcinoma: Preliminary Clinical Application

对照研究了鱼肝油酸钠乙醇混合液（ＳＭＰＡ）和无水乙醇（ＰＡＬ）肝癌瘤内局部注射的疗效。其中ＳＭＰＡ组３０个病灶，ＰＡＬ组３２个病灶。结果显示：ＰＡＬ组１例控制不佳，６例原位复发，其中２例原位复发伴门脉癌栓，２例较治疗结束时明显增大。ＳＭＰＡ组均控制良好，随访半至一年半无增大。彩色超声血流成像（ＣＤＦＩ）显示：ＳＭＰＡ较ＰＡＬ快速、完全栓塞肿瘤血管，两组结果有显著性差异（Ｐ值＜０．０５）。病理结果显示：ＳＭＰＡ组浸润区肿瘤细胞绝大部分凝固性坏死，瘤内血管绝大部分栓塞；ＰＡＬ组虽然在浸润中央区肿瘤细胞大部坏死，但在浸润周边区可见血管明显扩张，充血，在肿瘤的包膜上及其周围有较多的增生血管。我们认为：ＳＭＰＡ较ＰＡＬ是一种更为理想的肝癌瘤内局部注射药物。

Intratumor injections for the treatment of liver carcinoma using pure alcohol (PAL)(32 lesions), and sodium morrhuate pure alcohol (SMPA)(30 lesions) were investigated and compared. In PAL group, 1 case was not well controlled, 6 cases had tumor recurrence in site.Out of 6, cases 2 had significant enlargement of tumors with (2/6)or without (4/6) new portal thrombosis. In SMPA group, all cases were controlled after injection therapy. Reactive vascular thrombus appeared more quickly and effectively in SMPA group than PAL's on CDFI observation. There was significant difference between 2 groups (P<0.05). In SMPA group, the majority of tumor cells in injected area underwent coagulative necrosis , whereas in PAL group, although cells underwent necrosis in the central part of injected area, significently dilated and congested vessels could be found near the margin and new vessels proliferate in and around the capsule. It can be noted that SMPA is better than PAL in percutaneous intratumor local injection for the treatment of liver carcinoma.