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RNA干扰机制的分子生物学研究进展 被引量:5

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摘要 RNA干扰(RNAi)是一种有效的基因沉默过程。其主要机制是指双链RNA(dsRNA)在RNase Ⅲ作用下形成小干扰RNA(siRNA),进而与相应蛋白结合形成RNA诱导沉默复合物(RISC),介导靶mRNA降解。此外,RNAi还可作用于转录水平和翻译水平。本文介绍了RNAi的发现及可能分子机制。
出处 《国际病毒学杂志》 2007年第6期185-190,共6页 International Journal of Virology
关键词 RNAI SIRNA Dieer RISC
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