运动神经元病患者F波反应频率的研究

Study of F wave response frequency in patients with motor neuron disease

目的:探讨F波反应频率测定在运动神经元病(MND)中的诊断价值及其意义。方法:对43例MND患者(MND组)及18例对照组个体作F波反应频率、相同及不同形状F波反应频率、F波潜伏期、运动神经传导速度(MCV)、感觉神经传导速度(SCV)测定及对比分析。结果:MND组总的F波反应频率正中神经和尺神经分别为15%和28%,明显低于对照组(均为81%,P=0.001,P=0.00);MND组正中神经和尺神经相同形状及不同形状F波比率与对照组比较明显下降(P=0.00);与对照组比较,MND组正中神经与尺神经平均F波潜伏期都明显延长(P=0.00),正中神经和尺神经的MCV均减慢,差异有显著意义(P=0.00,P=0.01);两组的SCV比较差异则无显著意义(P=0.21,P=0.71)。结论:F波反应频率检测对MND的诊断及损伤程度判断可提供客观的电生理学依据。

Objective：To investigate the diagnostic value and physiological significance of F wave response frequency in patients with motor neuron disease （MND）. Methods： F wave response frequency of the same or different shapes, F wave latency, motor nerve conduct velocity （MCV） and sensory nerve conduct velocity （SCV） were measured. Forty-three cases of MND （MND group） and 18 cases of healthy individuals （the control group） were compared and analyzed. Results：F wave response frequency of median nerves and ulnar nerves significantly decreased in MDN group, compared with the control group （median nerves： 15% vs 81% ,P =0. 001 ; ulnar nerves： 28% vs 81% ,P=0. 001） ; Compared with the control group, F wave ratio with same or different shapes significantly decreased in MND group （P= 0. 001） ; Mean F wave latency of median nerves and ulnar nerves significantly increased in MND group, compared with the control group （P=0. 001）; MCV of median nerves and ulnar nerves significantly decreased in MNDgroup （median nerves： P=0. 001; ulnar nerves： P=0. 01）, while SCV of median nerves and ulnar nerves had no significant difference in MND and the control group （median nerves： P= 0.21; ulnar nerves： P= 0.71）. Conclusions： The measurement of F wave response frequency may provide objective and physiological data and evidence in the diagnosis of MND and estimation of the disease injury degree.