加减柴胡桂枝干姜汤对戊四唑诱导癫痫小鼠作用的实验研究

Experiment Study of a Modified decoction of Bupleuri,Cinnamomi and Zingiberis on Epileptic mice indued by pentylenetetrazol(PTZ)

目的:研究加减柴胡桂枝干姜汤不同剂量对戊四唑诱导小鼠痫性发作的影响。方法:2月龄昆明种小白鼠连续灌胃给药7天后,腹腔注射戊四唑造成癫痫模型,造模后1h,观察药物对小鼠癫痫发作潜伏期、行为分级、发作次数等的影响。结果:加减柴胡桂枝干姜汤可以显著延长小鼠癫痫发作潜伏期、改善痫性发作程度、发作次数,与模型组相比,差异具有统计学意义(P<0.05或P<0.01),与西药组相比,无显著性差异(P>0.05)。结论:加减柴胡桂枝干姜汤具有较好的抗小鼠戊四唑致痫作用,并存在一定的量效关系。

Objective： To study the effect of the different dose of a modified decoction of Bupleuri, Cinnamomi and Zingiberis on epiteptic seizure of mice induced by PTZ. Methods ： The mouse of two months was fed seven days, then was intraperitoneal inject PTZ to make epileptic models, After making models one hour , observed incubation period , behavior and times of epileptic seizure by the drugs. Results ： A modified decoction of Bupleuri, Cinnamoml and Zingiberis can prolong the incubation period and improve the degree and times of epileptic seizure remarkably. Comparing to model group, It has a statistical significance （ P 〈 0.05 or P 〈 0. 01 ）, And comparing to westerm medicine group, It has no statistical significance （ P 〉0.05 ）. Conclusion： A modified decoction of Bupleuri, Cinnamomi and Zingiberis can inhibit the epileptic seizure of mice induced by PTZ, and tend to present a dose -effect relationship between them.