下肢术后患者输注氯诺昔康镇痛对血小板功能的影响

Effects of platelet function on lornoxicam infusion for analgesia after lower limb orthopaedic surgerys

目的观察骨科下肢手术患者术后输注氯诺昔康对血小板功能的影响。方法将90例患者随机分为实验组(用氯诺昔康)、对照组(用芬太尼)及空白对照组,观察三组术前及术后24、48 h的P-选择素(GMP-140)、血栓烷B2(TXB2)、血小板聚集率(PAgT)变化。结果实验组各指标均明显低于其他组(P<0.01);组内与术前比较,实验组各指标降低(P<0.01),空白对照组升高(P<0.05),对照组变化不大。结论术后输注氯诺昔康对血小板功能有抑制作用。

[ Objective ] To investigate the effects of patient-controlled intravenous analgesia （PCIA） with lomoxicam infusion on platelet function in patients after lower limb orthopaedic surgerys. [ Methods] Ninety patients were randomly divided into 3 groups ： test group （0. 064% lomoxicam 100 ml）, control group （0.001% fentanyl 100 ml） and blank control group with 30 cases each. Both drugs were administered via PCIA for up to 48 homrs postoperatively. The plasma levels of P-selectin （GMP-140）, TXB2 and PAgT were detected before operation and 24, 48 homrs after surgery. [ Results] The levels of P-selectin, TXB2 and PAgT in test group were significantly lower than those in other groups after 24 or 48 homrs after surgery. But The levels of P-selectin, TXB2 and PAgT were significantly lower in control group and higher in blank control group than those in test group 24 or 48 hours later. [ Conclusion ] Lornoxicam infusion for PCIA may inhibit platelets activation, releasing and aggregation.