影响糖尿病患者胆固醇水平的多因素分析(附80例临床分析)

Analysis of multipe factor influencing cholesterol level in patients with diabetic mellitus:Clinical analysis of 80 cases.

本文观察８０例非胰岛素依赖型糖尿病（ＮＩＤＤＭ）患者的病程、糖化血红蛋白（ＧＨｂ）、甘油三脂（ＴＧ）、高密度脂蛋白－胆固醇（ＨＤＬ－Ｃ）、低密度脂蛋白－胆固醇（ＬＤＬ－Ｃ）、ＨＤＬ－Ｃ／ＬＤＬ－Ｃ、载脂蛋白Ａ１（ａｐｏＡ１）、载脂蛋白Ｂ１００（ａｐｏＢ１００）、ａｐｏＡ１／ａｐｏＢ１００、雌二醇（Ｅ２）、睾酮（Ｔ）、Ｅ２／Ｔ、尿白蛋白排泄率（ｕＡＥＲ）等因素对总胆固醇（ＴＣ）的影响，应用ＳＡＳ统计软件进行逐步回归分析。结果显示：ＴＣ与ＬＤＬ－Ｃ、ｕＡＥＲ显著正相关，与Ｅ２或Ｅ２／Ｔ显著负相关；而ｕＡＥＲ又与ＴＣ、ＧＨｂ、病程均显著正相关，提示ＮＩＤＤＭ患者胆固醇异常与脂蛋白代谢、性激素代谢、肾功能以及糖代谢等紊乱有关。

The article studies the relation of the serum total cholesterol (TC) with some factors in 80 patients with non-insulin-dependent diabetic mellitus (NIDDM).These factors include course,glycosylated hemoglobin(Ghb),triglyceride(TG),high density lipoprotein(HDLC),low density lipoprotein(LDL-C),HDL-C/LDL-C,apolipoprotein A 1(apoA 1),apoB 100 ,apoA 1/apoB 100 ,estrogenic hormone (E 2),testosterone(T),(E 2)/T,and rate of urinary albumin excretion(UAER) etc.The result of stepwise procedure in SAS revealed that TC has significantly positive correlation with LDL-C and UAER,that TC has significantly negative correlation with E 2 or E 2/T,that UAER has positive correlation with TC,GHb and course.It suggests that the abnormity of the cholesterol in NIDDM is relative with the abnormity of the lipoprotein,sex hormons,renal fuction and the glycometabolism.