双波长分光光度法考察注射用加替沙星与头孢吡肟配伍的稳定性

Determining compatible stability of cefepime with gatifloxacin by dual wavelength spectrophotometry

目的考察注射用加替沙星与头孢吡肟配伍的稳定性。方法在25℃条件下,观察6h内加替沙星(0.2g.L-1)和头孢吡肟(1g.L-1)配伍液的外观,测量pH值及用紫外光谱的变化,用紫外双波长等吸收法、系数倍率法分别测定注射用加替沙星与头孢吡肟的含量〔1～2〕。结果在0,2,4,6h时,两药在0.9%氯化钠注射液、5%葡萄糖注射液中配伍的含量,pH及外观基本不变。结论两种药物配伍液在6h内基本稳定。

OBJECTIVE To study the compatible stability of cefepime with gatifloxacin injection. METHODS Dual wavelength spectrophotometry and K-ratio spectrophotometry were used for the determination of cefepime （ 1 g · L^-1 ） with gatifloxacin （0. 2g · L^-1 ） injection during 6h,and at 25℃ for 6 hours the changes in appearance and pH were observed. RESULTS There was no evident variation in content during 0,2,4,6 hours for two injections mixing 0. 9% sodium chloride solution and 5% glucose solution for injection, no chang in appearance and pH. CONCLUSION The compatibility of cefepime with gatifloxacin injection is stable.