摘要
目的探讨奥氮平治疗急性期精神病的疗效及安全性。方法对住院的22例多种急性期精神病患者给予奥氮平治疗,观察两周。采用BPRS、CGI及TESS评定疗效及不良反应;评定时间为治疗前及治疗后第24小时、48小时、72小时、1周末、2周末。结果治疗72小时BPRS总分明显下降,与治疗前相比差异有显著性(P<0.05);第2周末时基本痊愈12例,显著进步6例,进步2例,无效2例,有效率90.9%。不良反应有轻度体重增加、嗜睡、乏力等。奥氮平平均日剂量为18.41±3.18mg。结论奥氮平对多种急性期精神病起效迅速,安全,不良反应少,患者依从性较好。
Objective To explore therapeutic effect and safety of Olanzapine in acute psychosis. Methods 22 patients in acute psychosis were treated with Olanzapine and observed for two weeks with BPRS, CGI and TESS in pretreatment and after 24 hours, 48 hours, 72 hours, 1 week, 2 weeks. Results Compared with the pretreatment, total scores of BPRS treated for 72 hours had significant difference（P〈0.05） After two weeks, there were 12 patients of clinic recovery, 6 of significantly effect, 2 of effect and 2 patients without response. The efficacy rates were 90.9 %. Adverse reactions included weight gain, drowsiness and debilitation, etc. Average daily doses of Olanzapine were （18.41± 3.18）mg. Conclusion Olanzapine is a taking effect fast, safety, low adverse reactions and good compliance antipsychotics for the treatment of acute psychosis.
出处
《中国健康心理学杂志》
2007年第12期1112-1113,共2页
China Journal of Health Psychology
关键词
奥氮平
精神病
疗效
Olanzapine
Psychosis
Therapeutic effect
