精神分裂症患者一级亲属的探索性眼球活动障碍研究

A study of exploratory eye movement dysfunction in first degree relatives of schizophrenia

目的:探讨精神分裂症患者一级亲属探索性眼球活动(EEM)障碍的发生率及与血清一氧化氮/一氧化氮合成酶(NO/NOS)水平的关系。方法:共收集精神分裂症患者一级亲属193名(研究组),健康对照者150名(对照组)进行EEM检查,同时检测血清NO/NOS水平。结果:精神分裂症一级亲属的EEM异常率(52.3%)显著高于对照组(14.7%)(χ2=52,P<0.01);在精神分裂症一级亲属中,具有EEM障碍者的血清NO和NOS水平显著低于无EEM障碍者(t=2.83,P<0.01;t=2.53,P<0.05)。结论:精神分裂症患者一级亲属EEM障碍的发生率增高,并可能存在血清NO/NOS水平低下。

Objective：To probe the incidence of exploratory eye movement dysfunction in first degree relatives of schizophrenia and its relationship with ratio of nitric oxide （NO）/nitric oxide synthase （NOS）. Method：193 first degree relatives of schizophrenia （study group） and 150 healthy controls（ control group） were enrolled in this study. All subjects tested examination of exploratory eye movement and were measured ratio of NO/NOS. Results： Compared with control group, patients in study group had a higher abnormal incidence of exploratory eye movement dysfunction （52.3 % vs 14.7 %, Х^2 = 52, P 〈 0.01 ）. In first degree relatives of schizophrenia, those with exploratory eye movement dysfunction had a significantly lower ratio of NO/NOS than patients without exploratory eye movement dysfunction （t=2.83,P〈0.01;t =2.53,P〈0.05） Conclusion：The first degree relatives of schizophrenia has a higher incidence of exploratory eye movement dysfunction and maybe has a lower ratio of NO/NOS.