聚氯乙烯软袋对腹膜透析液中川芎嗪的吸附

Adsorption of PVC bag containing peritoneal dialysis solutions on ligustrazine

目的：考察聚氯乙烯（ＰＶＣ）软袋装川芎嗪在腹膜透析液中的稳定性。方法：含川芎嗪０．０４ｍｇ·ｍｌ－１和０．２０ｍｇ·ｍｌ－１的腹膜透析液分别置于４℃，２５℃和３７℃，定时取样以ＨＰＬＣ测定含量，药物浓度降低≤５％为稳定性指标。结果：由于ＰＶＣ软袋的吸附作用，各浓度在２５℃６ｈ后均有显著性降低，１２ｈ后降至９５％以下；３７℃４ｈ即均有显著性降低，８ｈ后降至９５％以下。０．２０ｍｇ·ｍｌ－１（４℃）在２４ｈ后浓度明显下降，但１０ｄ后浓度下降未超过５％，０．０４ｍｇ·ｍｌ－１（４℃）在观察期间浓度略有升高。结论：ＰＶＣ软袋可吸附川芎嗪，随温度的升高，吸附作用亦增强。川芎嗪溶于腹膜透析液后室温贮放不宜超过６ｈ，温度升至３７℃后尽快使用。

OBJECTIVE: To evaluate the stability of ligustrazine (Lig) in PVC bag containing peritoneal dialysis solutions (PDS). METHODS: Lig 0.04 mg·ml -1 and 0.20 mg·ml -1 were stored at 4 ℃ for 10 days, 25 ℃ for 4 days and 37 ℃ for 1 day, respectively. Lig concentrations were measured by HPLC, the stability was defined as less than 5% decrease from initial concentration. RESULTS: Because the adsorption of PVC bag, Lig was below 95% after 12 h at 25 ℃ and 8 h at 37 ℃, respectively. In the solution storing at 4 ℃, 95% of the Lig (0.20 mg·ml -1 ) remained and 108.9% of Lig (0.04 mg·ml -1 ) were obtained after 10 days. CONCLUSION: The increment of adsorption was followed by the increase of temperature. The solutions should not store more than 6 h after Lig was added to PDS at 25 ℃ and rapidly employed after heated to 37 ℃.