摘要
目的研究p53和Bcl-2蛋白在舌鳞癌和癌前病变中的表达及意义。方法采用免疫组化SP法检测38例舌鳞癌(A组)、20例口腔癌前病变(B组)及10例正常口腔舌上皮组织(C组)中p53和Bcl-2蛋白的表达情况。结果比较A、B、C三组,p53和Bcl-2蛋白的表达在A组与C组、B组与C组之间,P均<0.05,在A组与B组之间,P>0.05;p53蛋白异常表达在淋巴结转移组显著高于无转移组,P<0.05;Bcl-2蛋白高表达与p53蛋白高表达之间无相关性,P>0.05。结论p53和Bcl-2蛋白高表达与舌鳞癌的发生、发展密切相关。
[ Objective ] To investigate the expression and significance of p53 and Bcl-2 proteins expression in tongue squamous cell carcinoma and precancerous lesions. [ Methods ] Immunohistochernistry staining SP method was used to detect p53 and Bcl-2 expressions in 38 cases of oral squamous cell carcinoma （ A group） , 20 cases of precancerous lesion （ B group） and 10 cases of normal oral tongue epithelium （C group）. [ Results] Comparison was done among A, B and C groups, expressions of p53 and Bcl-2 proteins were different between A group and C group （ P 〈 0.05 ）, B group and C group（ P 〈 0.05）, but have no difference between A group and B group（ P 〉0.05 ） ;Abnormal expression of p53 was obviously higher in positive lymph node metastasis group than that in negative lymph node metastasis group（ P 〈 0.05 ） ; Bcl-2 protein overexpression was not correlated with p53 protein overexpression （ P 〉 0.05 ）. [ Conclusion ] Overexpresslon p53 and Bcl-2 proteins is closely related to the genesis and development of tongue squamous cell carcinoma.
出处
《山东医药》
CAS
北大核心
2007年第33期17-18,共2页
Shandong Medical Journal
基金
辽宁省博士启动基金资助项目(20051011)。
