Rh(D)阴性孕妇产前免疫抗体水平与新生儿溶血病的关系

Correlation between immune level of Rh(D)-negative pregnant women and hemolytic disease of newborn

目的探讨Rh（D）阴性孕妇产前免疫抗体状态与新生儿溶血病的关系。方法回顾分析2003-2006年,35例RH（D）阴性孕妇的妊娠、分娩及其IgG抗D效价情况。结果在35例Rh（D）阴性孕妇中,初次妊娠18例,均未产生抗-D;两次以上妊娠17例,有5例产生抗-D,其中2孕次2例,效价均为1：2;3孕次2例,效价为1：8和1：32;4孕次1例,效价为1：256。结论在初次妊娠的Rh（D）阴性孕妇中,未见抗-D产生,孕次愈多,检测到的抗-D机率愈高;Rh抗体产生与个体免疫有关。

Objective： To determine the correlation between immune level of Rh （D） -negative pregnant women and hemolytic disease of newborn. Methods ： The clinical data of 35 Rh （D） - negative pregnant women during 2003 to 2006 was analyzed retrospectively, including gestation, delivery and their immune state. Results： Among 35 pregnant women of Rh （D） negative 18 cases are pregnant with first time who show no anti -D. There are 17 pregnant women with two and more pregnancy, 5 cases of them produced anti - D who are the second gestation in 2 women , the levels of the antibody is 1 ： 2. There are 2 women with 3 times gestation who are 1 ： 8 and 1 ： 32 in the antibody levels. One women who is 4 times gestation is 1 ： 256 in antibody level. Conclusion： No anti - D were observed in all first - time pregnant women with Rh （D） negative. The chance of anti - Rh （D） positive is enhanced with the times of pregnance. The produce of antibody is correlation with immune in individual.