卡维地洛与美托洛尔对慢性心力衰竭患者长期疗效比较

Comparision of Long-Term Effects of Metoprolol vs Carvedilol for Chronic Heart Failure

目的:观察两种β受体阻滞剂卡维地洛与美托洛尔对慢性充血性心力衰竭(CHF)的长期疗效。方法:慢性充血性心力衰竭患者65例,随机分为卡维地洛组32例,美托洛尔组33例,随访6个月,比较两组的心功能改善情况。结果:卡维地洛组及美托洛尔用药后两组患者左心室舒张末期内径(LVEDd)、左心室收缩期内径(LVEDs)、右心室内径(RVD)、左心房内径(LAD)显著缩小(均为P<0.01);左心室射血分数(LVEF)显著增加(卡维地洛组P<0.01,美托洛尔组P<0.05),且卡维地洛对LVEDs、RVD、LVEF的改善作用更优于美托洛尔(LVEDs、RVD均为P<0.01,LVEF为P<0.05)。结论:卡维地洛及美托洛尔均能明显改善心功能,提高生活质量,且卡维地洛疗效优于美托洛尔。

Objective：To assess the long -term effects of metoprolol and carvedilol on patients with chronic heart failure. Method：Sixty five patients with chronic congestive heart failure were randomly divided into two groups：metoprolol group, carvedilol group. The patients were followed up for 6 months. After 6 months of treatment both groups offered hemodynamic in the patients with heart failure. Result： After treating the two groups ＇ left ventricular end - diastolic dimension （ LVEDd ）, left ventricular end - systolic dimension （ LVEDs） ,right ventricular dimension（ RVD） ,left atrial dimension（ LAD） were significantly decreased（ P 〈 0.01 ）. The left ventricular ejection fraction（ LVEF） were significantly increased ,the carvedilol group（ P 〈 0.01 ） , The metoprolol group （ P 〈 0.05 ）. And the effect of Carvedilol is better than metoprolol （LVEDs, RVD P 〈0.01 ;LVEFP 〈0.05）. Conclusion： Both carvedilol and metoprolol can improve heart funtion obvi- ously, advance the quality of life, and carvedilol is better than metoprolol