慢性乙肝患者血清NO与肝纤维化关系探讨

Research the Relation of Hepatic Fibrosis with Serum NO in Patients with Chronic Hepatitis B

目的:研究慢性乙肝患者(CHB)血清一氧化氮(NO)、透明质酸(HA)、层粘蛋白(LA),IV型胶原(C-IV)血清水平的变化,探讨其在肝纤维化机制中的作用。方法:应用比色法、放免法测定107例CHB、20例健康成人血清NO、HA、LN、C-IV水平。结果:CHB轻、中、重度及肝硬化患者血清NO水平均显著高于对照组(P<0.01),并随着肝损害和肝纤维化程度的加重而升高,血清NO水平与血清HA、LN、C-IV水平呈相关(P<0.01)。结论:NO不仅与肝损伤密切相关,而且与肝纤维化程度相关,NO参与病毒性肝炎及肝纤维化的病理过程,检测NO有助于判断慢性肝病肝纤维化的程度。

Objective： To discuss the changes of serum nitric （ NO ）, hyalopasm acid （ HA ）, larninin （LN）and collagen type Ⅳ （C -Ⅳ） level on hepatic fibrosis mechanism by studying them in patients with chronic hepatitis B （ CHB ）. Method： The concentrations of serum NO, HA, LN, C - Ⅳ in 107 patients with CHB and 20 healthy adult were measured by colorimetry and radioimmunoassay. Result： The levels of serum NO in mild CHB group moderate CHB group , severe CHB group and liver cirrhosis （ LC） group were higher significant than that in the control （ p 〈0.01 ） ,and change with the degree of hepatic injury and fibrosis ,The level of serum NO was positive correlated with the levels of serum HA ,LN and C - Ⅳ（ p 〈0.01 ）. Conclusion： Serum NO is corresponding with not only hepatic injury , but also with hepatic fibrosis degree , NO takes , NO takes part in pathological process of viral hepatitis and hepatic fibrosis Testing the serum NO contributes to evaluating the hepatic fibrosis degree in patients with chronic hepatic disease