应用bFGF与EGF促进皮肤扩张的临床研究

The Clinical Study of Applying bFGF and EGF to Accelerate Skin Expansion

目的:探索碱性成纤维细胞生长因子(bFGF)和表皮生长因子(EGF)在扩张术中的临床应用方法与效果。方法:27例患者共埋置62个扩张器,随机分为治疗组和对照组,采用自身对照。治疗组在常规扩张的同时于扩张器周围注入bFGF与EGF,对照组仅常规扩张。测量两组扩张率、即时回缩率并进行统计学处理。结果:治疗组的扩张至额定容量的时间、即时回缩率较对照组减少(P<0.05),扩张率较对照组明显增加(P<0.01)。结论:bFGF与EGF能够促进扩张,降低皮瓣回缩率,提高皮瓣质量,改善治疗效果。

Objective： To search for the effect of local application of bFGF and EGF during tissue expan- sion. Method： 62 expanders in 27 patients were selected self - controlled in the study, and divided into treat -ment group and control group randomly, bFGF and EGF were injected around expanders during conven- tional expansion with only conventional expansion in control group. The expansion rate and the immediate re- traction rate of expanded skin were measured in two groups, and were carried on statistics analysis. Result： It reduced of the time to expand to rate capacity and the immediate retraction rate of expanded skin in treat- ment group comparing with them in control group （ P 〈 O. 05 ） , and the expansion rate obviously increased （ P 〈 O. O1 ）. Conclusion： Local application of bFGF and EGF during tissue expansion was feasible in patients. It could accelerate skin expansion and reduce the retraction rate of expanded skin.