轮状病毒肠炎患儿血清可溶性白细胞介素-2受体白细胞介素-10水平的变化和干扰素的调节作用

Changes and Regulation Effects of the Serums Level of IL-10 and SIL-2R at the Children Patient with Rotavirus Enteritis

目的:探讨IL-10、SIL?2R在轮状病毒肠炎发病和恢复中的临床意义。方法:将轮状病毒肠炎患儿40例分为干扰素组和非干扰素组,测定两组患儿急性期和恢复期IL-10和SIL?2R水平并与正常对照组比较。结果:急性期两组IL-10较正常对照组明显下降,有显著性差异(P<0.01);两组SIL-2R较正常对照组升高,有显著性差异(P<0.01);恢复期干扰素组SIL-2R、IL-10均较非干扰素组高,有显著性差异(P<0.01)。结论:轮状病毒肠炎时SIL-2R增高显示细胞免疫功能受抑,IL-10呈低水平状态显示机体免疫失衡,干扰素增强细胞免疫功能并纠正免疫失衡,促进轮状病毒肠炎恢复。

Objective： To explore the clinical meaning about the level of interleukin - 10 （ IL - 10 ） and soluble interleukin- 2 receptor （SIL -2R ） at the children patient with rotavirus enteritis during the acute stage and the recovery phase. Method： Divided the 40 patients into two groups, interferon group and non - interferon group, determinate their serums level of IL- 10 and SIL-2R at acute stage and recovery phase, and compare with the normal control. Result： At acute stage, compare the interferon group and the non - interferon group with the normal control, we find the levels of IL -10are evidently drop, the levels of SIL-2R are raising, and the difference is marked （p 〈0.01 ）. At recovery phase, compare the interferon group with the non - interferon group, we find the levels of SIL - 2R, IL - 10are raising and the difference is marked （ p 〈 0.01 ）. Conclusion： At the patient of rotavirus enteritis, the raising SIL - 2R level reveals the cellular immune function was restrained. The low level of IL - 10 reveals the immunity was imbalance. Interferon can accentuate the cellular immune function and correct the immunity unbalance, and facilitate the rotavirus enteritis to recover.