根除幽门螺杆菌对胃黏膜病变的影响

Effect of Helicobacter pylori Eradication on Gastric Mucosal Lesion

背景:幽门螺杆菌(H.pylori)被认为是导致胃黏膜病变的重要因子,根除H.pylori能使胃黏膜病变改善。目的:观察根除H.pylori对胃黏膜病变的影响。方法:予100例经胃镜和组织病理学检查确诊为萎缩性胃炎伴H.pylori感染患者抗H.pylori治疗,1年后复查胃镜和组织病理学,评定组织学变化。结果:所有患者均有不同程度的活动性炎症和慢性炎症。抗H.pylori治疗后,86例被根除。与根除前相比,根除后慢性炎症、活动性炎症、腺体萎缩程度评分均明显下降(P<0.01),肠化生评分无显著改善。结论:根除H.pylori对胃黏膜病变具有临床治疗意义。

Helicobacter pylori （H. pylori） is considered one of the important factors causing gastric mucosal lesion, which can be improved by H. pylori eradication. Aims： To investigate the effect of eradication of H. pylori on gastric mucosal lesion. Methods： One hundred patients with atrophic gastritis and H. pylori infection diagnosed by gastroscopy and histopathology were reexamined and reevaluated one year after H. pylori eradication. Results： All patients had various degrees of active and chronic inflammation, and 86 patients had their H. pylori eradicated after triple therapy. Score of chronic inflammation, active inflammation and glandular atrophy decreased significantly after H. pylori eradication （P〈0.01）, but no significant difference of score of intestinal metaplasia was found between before and after eradication. Conclusions： H. pylori eradication is of clinical value in ameliorating gastric mucosal lesion.