CC趋化因子及其受体与炎症性肠病

CC Chemokines and their Receptors in Inflammatory Bowel Disease

趋化因子是机体内一群能使白细胞发生趋化运动的小分子细胞因子,其中的CC趋化因子主要趋化和激活单核细胞和某些T细胞亚群,与炎症和免疫反应密切相关。炎症性肠病(IBD)是一种肠道慢性炎症性疾病,免疫反应异常为其重要特征。本文主要探讨CC趋化因子及其受体(CCR)与IBD发病机制的关系,以及两者在IBD诊断和治疗中的应用进展。

Chemokine is a family of small chemotactic cytokines that direct the migration of leukocytes. CC chemokine is a group of chemokines that mainly chemoattracts and activates the mononuclear cells and some T cell subsets and is closely related to inflammatory and immune reaction. Inflammatory bowel disease （IBD） is a chronic inflammation of intestinal tract, which is characterized by abnormal immune reaction. This review article discussed the relationship between CC chemokines, their receptors （CCR） and the pathogenesis of IBD, as well as the use of CC chemokines and CCR in the diagnosis and treatment of IBD.