树突状细胞与肠道免疫调节

Dendritic Cell and the Immunomodulation of Intestinal Tract

淋巴组织、固有层和肠上皮散布的免疫效应细胞构成了肠道免疫调节网络,对维持机体内环境稳态起重要作用。树突状细胞(dendritic cell,DC)广泛分布于整个肠道免疫系统中,是重要的抗原呈递细胞之一,参与免疫调节。由于DC在不同肠道部位、不同成熟阶段、不同特异性亚型,产生不同的免疫调节功能,即免疫激活或免疫耐受,可能对炎症性肠病(IBD)和其他免疫性疾病的发生、发展起重要作用。

The immunomodulation network of intestinal tract, constituted by lymph tissue and immune effector cells dispersed in the lamina propria of the intestinal tract and enteric epithelium, plays a major role in maintaining homeostasis. Dendritic cell （DC）, widely dispersed in immune system of the entire intestinal tract, is one of the important antigen presenting cells and participates in immunological regulation. DC may play a key role in the development of inflammatory bowel disease （IBD） and other immunologic diseases for its different immune regulating functions in different parts of intestinal tract, different stages and different sub-types of specificities leading to immunotolerance and immunity.