血管细胞粘附分子-1与妊娠期高血压疾病的相关性

Study of the relationship between vascular cell adhesion molecule-1 and hypertensive disorder complicating pregnancy

目的:探讨血管细胞粘附分子-1(VCAM-1)在妊娠期高血压疾病中的病理生理作用及二者的相关性。方法:用酶联免疫吸附法(ELISA)对29例妊娠期高血压疾病患者(分妊娠期高血压组7例,子痫前期组22例),15例正常妊娠孕妇(正常孕妇组),分3个孕期即16～21周、25～28周、33～42周,14例非孕健康育龄妇女(正常对照组),所有对象均抽取清晨空腹肘静脉血测定血浆VCAM-1值。结果:子痫前期组VCAM-1值(1471.95±423.12)ng/ml与妊娠期高血压组VCAM-1值(880.49±256.63)ng/ml相比明显升高,有显著性差异(P(0.01),妊娠期高血压组的VCAM-1值与正常孕晚期组(936.31±217.53)ng/ml相比,无显著性差异(P>0.05),正常孕晚期组VCAM-1值与正常对照组(614.91±412.99)ng/ml比较,有显著性差异(P(0.02),正常孕妇组不同孕龄的VCAM-1值比较,无显著性差异(P>0.05)。结论:外周血中VCAM-1水平变化与妊娠期高血压疾病密切相关,随着病情加重VCAM-1值明显升高,VCAM-1对预测子痫前期的发生、发展及终止妊娠时机的选择有重要作用;VCAM-1值在正常妊娠中不随孕龄的增长而升高。

Objective： To discuss the role of pathogenesis of vascular cell adhesion molecule - 1 （ VCAM - 1 ） in patients with hypertensive disorder complicating pregnancy, and to discuss the relationship between VCAM - 1 and hypertensive disorder complicating pregnancy. Methods： The fasting plasma of VCAM - 1 were measured by ELISA in 29 patients with hypertensive disorder complicating pregnancy （7 cases with gestational hypertention, 22 cases with pre - eclampsia）, 15 healthy pregnant women at 16 to 21weeks＇gestation and 25 to 28 weeks＇gestation and 33 to 42 weeks＇gestation, respetively （normal pregnancy group）, 14 nomal healthy no pregnant women （normal control group） . Results： The plasma levels of VCAM - 1 in patients with pre - eelampsia group （ 1471.95± 423. 12） ng/ml were significantly higher than those in patients with gestational hypertention group （ 880. 49 ± 256. 63） ng/ml （P 〈 0. 01 ） . There was not significantly different between the plasma levels of VCAM - 1 in patients with gestational hypertention group and those in normal later - pregnant women group （936. 31 ±217. 53） ng/ml （ P 〉0. 05） . The levels of plasma VCAM - 1 in healthy later - pregnant women were significantly increased than those in normal control group （614. 91 ±412. 99） ng/ml （P 〈0. 02） . The levels of plasma VCAM - 1 were no significantly different in normal pregnant group at different trimester （P 〉 0. 05） . Conclusion： The levels of plasma VCAM - 1 increase with the severi- ty of patients with hypertensive disorder complicating pregnancy. The levels of plasma VCAM - 1 specially play a important role to predict the severity of patients with pre - eclampsia It is important to predict the change of their levels for termination of labour. The levels of plasma VCAM - 1 are not increased with pregnant progress.