Survivin在卵巢癌中的表达及其与诊疗、预后关系的研究

Expression and clinical significance of anti-apoptosis gene survivin in ovarian epithelial carcinoma

目的:观察正常卵巢、良性卵巢上皮性肿瘤、上皮交界性肿瘤、卵巢上皮性癌组织中凋亡抑制基因Survivin的表达,探讨Survivin的表达与卵巢上皮性癌诊疗、预后的关系。方法:用免疫组织化学法(SP法)检测32例正常卵巢、30例良性卵巢上皮性肿瘤、11例卵巢上皮交界性肿瘤、52例卵巢上皮性癌组织中Survivin的表达。结果:Survivin蛋白在卵巢上皮交界性肿瘤和卵巢上皮性癌组织中的表达率分别为63.6%、69.2%,明显高于卵巢上皮良性肿瘤及正常卵巢组织的表达率6.25%、30.0%(P<0.05)。卵巢上皮性癌组织中的Survivin表达率稍高于卵巢上皮交界性肿瘤,两者差异无显著性(P>0.05)。Sur-vivin蛋白的表达与肿瘤病理分级、淋巴结转移、腹水有无、临床分期及手术后残余肿瘤的大小相关(P<0.05)。结论:Survivin蛋白在卵巢癌的发生、发展中起一定作用,可以作为早期诊断、评价疗效、判定预后的重要指标。

Objective： To investigate the expression of a novel inhibitor of apoptosis Survivin in ovarian neoplasms and its correlation with clinieopathohgieal faetors and prognosis. Methods： The expression of Survivin was detected immunohistochemieaUy in 32 cases of normal ovarian tissues, and 30 eases of benign epithelial tumor, 11 eases of borderline epithelial tumor, 52 eases of malignant epithelial tumor. Results： Survivin expression was detected in 69. 2% of malignant epithelial tumor and 63. 6% of borderline epithelial tumor, higherthan 30% of benign epithelial tumor, 6. 25% of normal ovarian tissues. Overexpression of Survivin was related to the tumor grade, clinical stage, lymph node metastasis, ascites, residual tumor size. Survivin gene expression was no related to age and histological subtype. Conclusion： Survivin plays an important role in the progression of malignancy and is an import predictive/prognostic parameter in ovarian tumor.